ERBP guideline on transplantation

European Renal Best Practice (ERBP) under the auspices of ERA-EDTA has prepared guidelines concerning the evaluation and preparation of donor and recipient of a kidney transplant, in the pre-transplant and peri-operative period. During the spring of 2013 members of ERA-EDTA as well as members of the Descartes working group were invited to review these guidelines. A total of 675 responded and the guidelines have now been finalized and are to be published in the August issue of NDT. The Descartes Board wishes to thank all Descartes working group members participating in the review process for their valuable collaboration.

DESCARTES in collaboration with European Renal Best Practice (ERBP) worked on guidelines for pre-emptive living donor transplantation. The working group was chaired by Wim Van Biesen from ERBP and includes Maria Haller from ERBP method support team, Daniel Abramowicz, Umberto Maggiore, Rainer Oberbauer, and Marc Hazzan all from DESCARTES as well as Pierre Cochat and Licia Perizzi both paediatric nephrologists. The guidelines are currently under submission.

Scientific activities

The Descartes initiative on a pan-European trial on optimizing the immunosuppressive therapy after kidney transplantation in the elderly was conceived in the autumn of 2012. Since then the development has been very fast.  As already mentioned the study is now proceeding as a joint venture with the ESOT Kidney Committee. A major obstacle to such a study, the funding, seems to be manageable as the study synopsis has received very good review from major potential sponsors. At present Descartes is funding the writing of the detailed protocol, and the more detailed planning of logistic and economical aspects of the study is on-going.
The Descartes initiative on operational tolerance starting with a survey in European centres is proceeding as planned. The first step was to approach the group from Nantes (Sophie Brouard and Magali Giral) well known for their research in this field. This approach has been successful, and the study is now proceeding as a joint Descartes/Nantes initiative. At present work is done to launch a survey to define the prevalence of tolerant and nearly tolerant patients across Europe. The intention is that this mapping can be the basis for further investigations based on biological material from these patients.

Educational activities