DESCARTES major plan is to set up clinical trials whose main characteristics are:
1) to focus on unambiguous, meaningful clinical endpoints;
2) to include estimates of cost and cost-effectiveness;
3) to set up trials with sufficiently long follow-up time;
4) to enrol patients that are usually excluded from industry-driven clinical trials.
5) to provide a network of clinical trial sites for future translational research projects

The current tentative topic for the first clinical trial of the DESCARTES WG is a randomized controlled trial of immunosuppressive therapy in the elderly, a field where sound, robust data are still lacking. At a later stage, other projects combining clinical and biological research will be considered.